胎脑黑质细胞悬液脑实质内移植与脑室内移植的效果比较

Intraparenchymal and intraventricular transplantation of fetal substantia nigra cell suspenson in rat model of Parkinson's disease

为了比较胎脑黑质细胞悬液脑实质内移植与脑室内移植的效果,作者观察了接受上述移植处理后的PD大鼠旋转行为的变化和移植部位组织学及免疫组化特征,结果发现胎脑黑质细胞悬液脑实质内移植有利于移植物对宿主脑组织形成神经再支配,其远期效果比脑室内移植的效果更稳定、更持久。

The grafts of fetal substantia cell suspension grafts could bring into a behavioral effect and characteristics of histology and immunocytochemistry in rat models of PD after the grafts were transplanted either into the lateral ventricles or directly into the striatum. It was found that the intraparenchymal tromsplantation of fetal nigral cell suspensions not only was beneficial to reinnervation between host and grafts, but also produced more complete and steady effects than the intraventricular transplantation. We concluded that the restoration of nervous functional deficits of PD rats is likely to depend on both extensive dopaminergie reinnervation throughout the grafted sites and on closer integration of the grafts with the host striatal circuitry.