老年高血压患者脉压与颈动脉内膜中层厚度关系

Relationship between pulse pressure and carotid artery intima-media thickness in elderly with essential hypertension

目的观察老年高血压患者动态血压的变化,以及脉压与颈动脉内膜中层厚度的相关性。方法测量103例老年高血压患者24h动态血压,计算昼夜之脉压及脉压的变化幅度,根据脉压分为两组:脉压小于60mmHg的低脉压组和脉压大于或等于60mmHg的高脉压组;用多普勒超声检查颈动脉内膜中层厚度。比较两组血压参数与内膜中层厚度的差异,分析内膜中层厚度和脉压各项指标的相关性。结果高脉压组与低脉压组的颈动脉内膜中层厚度差异有统计学意义(P<0.01),脉压与颈动脉内膜中层厚度有较好的相关性。结论老年高血压患者的脉压尤其是夜间脉压与颈动脉内膜中层厚度明显相关。

Objectives To study the relationship between ambulatory pulse pressure （PP） and carotid artery intima-media thickness in elderly patients with essential hypertension. Methods The 24 hours ambulatory blood pressure monitoring was performed in a total of 103 elderly patients with essential hypertension. According to day-and night-time average PP, the patients were divided into two groups： PP〈60 mm Hg group and PP≥60 mm Hg group. The ultrasound technique was used to detect the carotid artery intima-media thickness. The comparison of difference of the carotid artery intima-media thickness and the correlative analysis of every parameter of the carotid artery intima-media thickness and PP in two groups was done. Results There was significantly different in the carotid artery intima-media thickness between PP〈60 mm Hg group and PP ≥ 60mmHg group （P〈0.01）. There was better correlation of PP and the carotid artery intima-media thickness, especially the correlation of nocturnal PP and the carotid artery intima-media thickness was the best. Conclusions The ambulatory PP （especially nocturnal PP） of the elderly patients with essential hypertension are the most important factors which influent the carotid artery intima-media thickness.