免疫抑制对大鼠浅Ⅱ度烧伤创面转移生长因子α,β和血小板衍生生长因子表达的影响

THE mRNA EXPRESSIONS OF TGF α、β AND PDGF WITHIN THE HEALING WOUND AFTER SUPERFICIAL BURN WITH IMMUNOSUPPRESSION IN RATS

为将６０Ｃｏ照射造成免疫抑制，观察全身免疫抑制对浅Ⅱ度烧伤创面局部转移生长因子α、β（ＴＧＦ－α，ＴＧＦ－β）和血小板衍生生长因子（ＰＤＧＦ）ｍＲＮＡ表达的影响。结果显示：正常组渗液细胞中这３种因子的表达极少。与免疫抑制组相比，烧伤对照组的ＰＤＧＦ和ＴＧＦ－α在伤后１ｄ和３ｄ明显升高，而免疫抑制组无明显变化。ＴＧＦ－β在两组均有表达。说明创面局部生长因子ＰＤＧＦ和ＴＧＦ－α的表达减少是免疫抑制造成创面愈合不良的直接原因。ＴＧＦ－β的变化反映其生物学作用的复杂性。

the effects of immunosuppression on the mRNA expressions of TGF α,β and PDGF within the healing process of superficial wound in burns were studied.It was rare that the mRNA of these three growth factor expressed in NC group.The mRNA of PDGF in BC group expressed higher than that in IS group,97% vs .4% at PB 1d,20% vs .0 at PB 3d.The expression of TGF α in BC group is also higher than that in IS group,96% vs . 0 at PB 1d,34% vs. 3 3% at PB 3d.There is not significant distinct between the BC and IS group that express the TGF β.