摘要
大鼠注射内毒素后1~72h6个时相点,肺组织主要病变为充血、瘀血、水肿,不同程度的肺萎陷;肺泡Ⅱ型上皮(PⅡ)肿胀、退变。肺组织匀浆表面活性物质(PS)含量及活性下降,肺泡隔面积密度相应增加,二者呈显著负相关(r=-0.9395,P<0.01)。于注射内毒素后1~48h改变最为明显。结果表明,内毒素可直接或间接致PⅡ及PS系统受损,进而促进肺水肿、肺萎陷的发生和呼吸窘迫综合征的形成。
The ultrastructural changes of lung,pulmonary homogenates sufactant (ST) and the area density of alveolar septa were investigated at 1,5,12,24,48 and 72h after lipopolysaccharide (LPS) injection.The most prominent changes were pulmonary tissue congestion,edema,collapse,type Ⅱ epithelial cells (PⅡ) swelling and degeneration.ST content and it's activity decieased while the area density of alveolar sepat increased.They had a significanly negtive correlation ( r =-0 9395, P <0 01).The above changes were more severe 1 to 48h after LPS injection.The results indicated that LPS may cause direct or indirect damage to the PⅡ and ST system and that it accelerate the development of pulmonary edema,collapse and respiratary distress syndrome.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1997年第1期60-62,共3页
Medical Journal of Chinese People's Liberation Army