肠易激综合征回盲部肥大细胞的研究

MAST CELLS OF ILEOCECAL JUNCTION IN IRRITABLE BOWEL SYNDROME

为探讨肠易激综合征（ＩＢＳ）回盲部肥大细胞计数有无变化，以及它的可能作用及临床意义，应用组化染色法检测了１９名正常人及２０例ＩＢＳ患者回盲部肥大细胞的计数，同时应用免疫组化和电镜观察研究肥大细胞与神经纤维的关系。结果：ＩＢＳ患者回盲部肥大细胞计数明显增多（Ｐ＝０．０１９）；神经纤维与肥大细胞密切毗邻，神经纤维多是无髓神经纤维。结果提示肥大细胞在ＩＢＳ的病理生理过程中可能发挥着一定的作用，在肠道和神经系统之间可能是它们相互联系和相互影响的一种中间媒介。认为肥大细胞稳定剂或肥大细胞产物拮抗剂对ＩＢＳ可能具有治疗作用。

To investigate whether the mast cells(MC) of the ileocecal junction(ICJ) is elevated in the irritable bowel syndrome(IBS) and the possible roles of the MC in IBS, the biopsies of ICJ were stained specifically by histochemistry for the MC in the IBS group( n =20) and the normal group( n =19).The structure relation between MC and nerves was studied through an electronic microscopy and an immunohistochemical method demonstrating neuronspecific enolase.The results demonstrated that the number of the MC of ICJ was significantly elevated in the IBS( P =0.019) and that mast cells were close to nerves which were often unmyelinated nerves in lamina propria. The results indicate that the MC of ICJ may be responsible for the pathophysiology of the IBS. We conclude that the MC of ICJ may be a mediator between the gut and the nervous system in the IBS, and that the mast cell stabilizer or the antagonists of the mast cell products may have potential treatment effects on the IBS.