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不同气腹压力对大鼠系统免疫功能的影响 被引量：4

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摘要 目的观察不同气腹压力对大鼠系统免疫功能的影响。方法模拟不同气腹压力CO2气腹腹腔镜手术,时间为1h。将60只雌性S-D大鼠随机分为4组,每组15只,各组气腹压力分别为①0mmHg,②5mmHg,③10mmHg,④15mmHg。分别于手术第0,1,3,7天检测大鼠血液中CD3,CD4和CD8T细胞的数值变化,了解不同气腹压力对大鼠系统免疫功能的影响。结果术后第1天各组CD细胞计数值均明显下降(P<0.01),第4组(15mmHg)最低,免疫抑制最明显(P<0.01)。5,10mmHg气腹组居中(P<0.05),两组CD细胞计数下降程度基本相同(P>0.05)。第1组(0mmHg)CD细胞计数下降程度最小,免疫抑制程度最低。术后第3天各组免疫功能逐渐恢复,第1组恢复最快(P<0.01),第4组恢复最慢(P<0.01);2,3组居中。术后第7天各组CD细胞计数均恢复术前正常水平(P>0.05)。结论随着气腹压力增高,对系统免疫功能抑制程度逐渐增大,术后免疫功能恢复较慢,临床手术时不宜采用过高气腹压力,以减少对免疫功能的抑制。
作者 张团英 陈旭 张凤兰
机构地区 广东医学院附属医院妇产科 中国人民解放军第
出处 《广东医学》 CAS CSCD 北大核心 2007年第7期1039-1041,共3页 Guangdong Medical Journal
关键词 腹腔镜手术 CO2气腹 气腹压力 系统免疫功能
分类号 R392.1 [医药卫生—免疫学]
  • 相关文献

参考文献13

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二级参考文献13

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  • 10Decker D, Schondorf M, Bidlingmaier F, et al. Surgical stress induces a shift in the type l/type 2 T- helper cell balance, suggesting down - regulation of cell mediated and up - regulation of antibody- mediated inamunity commensurate to the tratuma. Surgery,1996; 119:316 -325.

共引文献11

同被引文献22

引证文献4

二级引证文献20

广东医学
2007年 第7期

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