乳腺癌和导管内增生性病变CD105的表达及其临床意义

Expression of CD105 and clinic significance in breast carcinomas and intraductal proliferative lesions

目的探讨CD105在乳腺癌和乳腺导管内增生性病变中的表达及其作为肿瘤新生血管标志物的临床价值。方法检测70例乳腺癌、64例乳腺导管内增生性病变和18例正常乳腺组织中CD105及三种促血管生成因子VEGF、bFGF和PDGF的表达,并对其与临床病理因素进行分析。结果CD105标记的微血管密度(MVD)各组间差异均有统计学意义,病变区周围MVD明显高于病变区内的MVD,差别具有统计学意义;组织学分化程度低、临床TNM分期高、淋巴结转移阳性以及VEGF、bFGF和PDGF表达阳性的患者中,CD105表达明显升高,差别均有统计学意义。结论CD105主要在处于增殖状态的血管内皮细胞上表达,在标记肿瘤组织新生血管方面的特异性优于泛血管内皮细胞标志物,可作为乳腺癌预后的重要指标之一。

Objective To discuss the expression of CD105 in breast carcinomas and intraductal prolife rative lesions, and the clinical importance of CD105 as a marker for new born neoplasm-related microvessels of tumor. Methods To detect the expression of CD105 and VEGF, bFGF and PDGF in 70 cases of breast cancers, 64 cases of intraductal proliferative lesions, 18 cases of normal breasts, and to analyze them. Results The microvessel density （MVD） based on CD105 expression had statistical significance in differences groups, MVD adjacent to the lesion was significantly higher than those within the lesion in every group （P〈0.01 for each）. High level of CD105 expression was demonstrated in the case with low difierentiated cases, late TNM stages, metastasis of lymph node and expression of VEGF, bFGF and PDGF. Conclusion CD105 is strongly expressed on proliferating vascular endothelium and specific in marking the activity microvessel of tumor. Investigating CD105 will contribute to prediction of the prognosis in breast cancer.