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5-溴苯并呋喃酮的合成方法研究 被引量：4

Method for Synthesis of 5-Bromophthalide
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摘要 5-溴苯并呋喃酮是合成西酞谱兰(Citalopram)的重要中间体。报道了在冰醋酸中,Co(OAc)2-Mn(OAc)2-NaBr催化4-溴邻二甲苯氧化合成5-溴苯并呋喃酮的方法,收率良好。 5-Bromophthalide, a key intermediate of citalopram, was synthesized by treatment of 4-bromo-o-xylene catalyzed by Co（OAc）2-Mn（OAc）2-NaBr with oxygen using acetic acid as solvent in satisfactory yield.
作者 韦国兵 胡奇军
机构地区 江西中医学院药学院
出处 《精细化工中间体》 CAS 2007年第2期44-45,共2页 Fine Chemical Intermediates
关键词 5-溴苯并呋喃酮 催化氧化 4-溴邻二甲苯 5-bromophthalide catalytic oxidation 4-bromo-o-xylene
分类号 O623.624 [理学—有机化学]
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参考文献7

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同被引文献46

  • 1全哲山,赵立明,李福男,朴虎日.2,3-二取代-5-羟基苯并呋喃衍生物的合成[J].有机化学,2004,24(12):1637-1639. 被引量：3
  • 2龚润军,周宇涵,苗蔚荣,孟庆伟,彭孝军.2-溴-6-氯-3-(2H)-苯并呋喃酮的合成[J].精细与专用化学品,2005,13(7):12-13. 被引量：1
  • 3张留印,王国平,周臻,刘妮.5-氟-2,3-二氢苯并呋喃的合成[J].中国医药工业杂志,2005,36(6):324-325. 被引量：2
  • 4吕亮,吾国强.抗抑郁药西酞普兰中间体5-溴苯酞的合成[J].中国药学杂志,2006,41(24):1905-1908. 被引量：5
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  • 6Pulla, Reddy, Muddasani. Process for the preparation of citalopram[P]. WO: 02 066 453, 2002-08-29.
  • 7Killin, Stephen, James, et al. Improved process for the manufacture of citalopram hydrobromide from 5-bromophthalide[P]. EP: 1 282 211, 2003-03-05.
  • 8Nandkumar C, Ajit B, Oak G M, et al. Process for the manufacture of citalopram hydrobromide from 5-bromo- phthalide[P]. US: 2 004 077 870, 2004-03-22.
  • 9Muddasani, Pulla, Reddy , et al. Process for the preparation of high purity citalopram and its pharmaceutically acceptable salts[P]. US: 2 004 016 602, 2004-02-26.
  • 10Jaweed M, Siddiqui, Mohammed, et al. Improved process for the manufacture of citalopram hydrobromide[Pl. WO: 200 5 042 473, 2005-05-12.

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精细化工中间体
2007年 第2期

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