3-甲基-4-丁酰胺基-5-硝基苯甲酸甲酯的合成

Synthesis of Methyl 3-methyl-4-[(1-oxobuthyl) amino]-5-nitrobenzoate

以3-甲基-4-硝基苯甲酸为原料,经酯化、催化加氢、缩合、硝化和精制,合成了两个医药中间体:3-甲基-4-正丁酰胺基苯甲酸甲酯和3-甲基-4-正丁酰胺基-5-硝基苯甲酸甲酯,并通过1H NMR和IR验证了其结构。

Two intermediates of pharmaceuticals, Methl 3-methyl-4-（1-oxobuthyl） aminobenzoate and Methyl 3-methvl -4 -F （1-oxobuthvl）amino] -5 -nitrobenzoate, were synthesized from 3-methyl-4-nitrobenzoic acid by esterification, catalytic hydrogenation, acylamination, nitration and refinement. They were characterized by ^1H NMR and IR.