食管黏膜不同病变阶段患者血清Ep-CAM水平及临床意义

The Clinical Significance and Level of Ep-CAM Eexpression in the Sera of the Patients with Different Pathological Changes of Esophageal Mucosa

目的探讨上皮细胞黏附分子(Ep-CAM)在食管癌、食管黏膜不典型增生患者血清中的表达水平及意义。方法应用酶联免疫(ELISA)的方法,检测正常对照人群、食管黏膜不典型增生、食管癌患者血清中Ep-CAM的表达水平。结果p-CAM在正常对照、食管黏膜不典型增生、食管癌患者血清中的水平呈梯度升高,P<0.01;中、重度不典型增生患者血清中的Ep-CAM表达水平明显高于轻度组,P=0.036;Ep-CAM表达水平与食管癌的转移明显相关,P<0.001,且在手术前后表达水平明显降低,P<0.001。结论患者血清中Ep-CAM表达水平的变化出现在食管黏膜病变的早期阶段,其表达与食管癌的发生发展明显相关,可作为疾病监测的特异指标。

Objective To investigate the clinical significance and level of epithelial cellular adhesion molecule （Ep- CAM） expression in the sera of the patients with esophageal cancer or esophageal atypical hyperplasia. Methods We examined Ep-CAM expression by enzymelinked immunosorbent assay （ELISA）. Results The Ep-CAM level in serum was significantly different in the normal, esophageal cancer and esophageal atypical hyperplasia groups, P 〈 0.01. The Ep-CAM level of moderate dysplasia and hyperplasia groups was higher than the mild dysplasia,P = 0.036. The serum Ep-CAM level was associated with metastasis of esophageal cancer, The serum Ep-CAM level was significantly reduced after operation, P 〈 0. 001. Conclusion The enhanced expression of Ep-CAM is an early step in the malignant transformation of epithelium, and can be used as a marker for diagnostic purpose.