血浆溶血磷脂酸检测在妇科恶性肿瘤诊断中的应用研究

The Value of Plasma Lysophosphatidic Acid Measurement in the Diagnosis of Gynecology Tumor

目的探讨血浆溶血磷脂酸(LPA)检测在妇科恶性肿瘤特别是卵巢癌诊断中的临床意义。方法检测191例妇科恶性肿瘤和40例妇科良性疾病患者及40例健康献血员血浆溶血磷脂酸含量,同时测定卵巢癌患者血浆CA125含量,并作对比分析。结果卵巢癌组、宫颈癌组及子宫内膜癌组患者血浆LPA水平分别为(5.98±2.49)、(4.81±2.12)和(4.56±2.16)μmol/L与正常对照组的(2.31±0.45)μmol/L比较,有显著性差异(P均<0.01),三者阳性率分别为86.3%、62.5%及65.0%;乳腺癌组、白血病组及妇科良性疾病组与正常对照组比较,有显著性差异(P>0.05);血浆LPA和CA125对卵巢癌诊断的敏感性和特异性分别为86.3%、75.0%和92.3%、73.1%。结论血浆LPA检测对妇科恶性肿瘤特别是对卵巢癌的诊断及鉴别诊断可能具有潜在的临床应用价值。

Objective To study the value of measurement of plasma lysophosphatidic acid （LPA） in the diagnosis of gynecology tumor, Methods Plasma LPA levels from 191 patients with gynecology tumor ,40 patients with gynecology benign disease and 40 healthy control women were measured, The plasma CA125 levels were measured from patients with ovarian cancer at the same time, Results Plasma LPA levels were significantly higher in ovarian cancer（5.98 ± 2.49） umol/L, cervical carcinoma （4.81 ± 2.12）μmol/L and endometrial carcinoma （4. 56 ± 2.16） μmol/L than those in the healthy control group （2, 31 ± 0, 45 ）μmol/L（P 〈 0.01 ）, The positive rate of plasma LPA in ovarian cancer , cervical carcinoma and endometrial carcinoma were 86, 3% ,62.5% and 65. 0%, respectively, There were no significant differences in plasma LPA levels among patients with breast cancer,leukemia, gynecology benign disease and healthy control women （P 〉 0, 05 ）, The sensitivity and specificity of plasma LPA for ovarian cancer were 86.3% and 92.3%, whereas the sensitivity and specificity of CA125 were 75.0% and 73.1%. Conclusion Plasma LPA levels may have a potential value in the diagnosis of ovarian cancer.