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PTEN与内分泌肿瘤关系的研究进展 被引量:1

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作者 卢瑶 罗佐杰
出处 《实用癌症杂志》 2007年第4期431-433,共3页 The Practical Journal of Cancer
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  • 1Steck PA, Pershouse MA, Jasser SA, et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers[J]. Nat Genet, 1997,15(4): 356-362.
  • 2Myers MP, Stolarov JP, Eng C, et al. P-TEN, the tumor suppressor from human chromosome 10q23,is a dual specificity phosphatase [J]. Proc Natl Acad Sci USA, 1997, 94(17):9052-9057.
  • 3Weng LP, Brown JL, Eng C. PTEN coordinates G1 arrest by down-regulating cyclin D1 via protein phosphatase activity and upregulating p27 via its lipid phosphatase activity in a breast cancer model[J]. Hum Mol Genet, 2001,10(6) : 599-604.
  • 4Pernicone PJ, Scheithauer BW, Sebo TJ,et al. Pituitary carcinoma : a clinicopathologic study of 15 cases[J]. Cancer, 1997,79(4) :804-812.
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  • 8Yoshimoto K, Tanaka C, Yamada S, et al. Infrequent mutations of p16INK4A and p15INK4B genes in human pituitary adenomas[J]. Eur J Endocrinol, 1997,136(1) : 74-80.
  • 9Cantley LC,Neel BG. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci U S A, 1999, 96: 4240-4245.
  • 10Zhong H, Chiles K, Feldser D, et al. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res, 2000, 60: 1541-1545.

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