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Nogo基因及其相关蛋白与中枢神经再生的研究进展 被引量:1

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摘要 Nogo蛋白(勿动蛋白)与NgR(勿动蛋白受体)和中枢神经再生抑制密切相关。nogo基因编码的三种蛋白质:Nogo-A、Nogo-B和Nogo-C是中枢神经系统髓鞘中具有抑制神经生长活性的跨膜蛋白。Nogo受体是一种糖基醇磷脂结合蛋白,Nogo-66与p75NTR-NgR形成的受体复合物结合导致生长锥塌陷及神经突起生长的抑制。本文主要就nogo基因及其产物的研究概况及其在中枢神经系统损伤后神经再生修复方面可能的应用前景进行综述。
作者 丁月霞 李林
出处 《中国药理通讯》 2007年第2期18-18,共1页
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  • 2赵湘辉,金卫林,MI Sha,鞠躬.LINGO-1-Fc蛋白对低钾诱导小脑颗粒神经元凋亡的保护作用[J].生物化学与生物物理进展,2006,33(4):336-342. 被引量:5
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