摘要
本研究应用Ｐ５３蛋白单克隆抗体对７８例软组织肉瘤行免疫组化染色，并对各种软组织肉瘤组织中Ｐ５３蛋白的表达进行了分析研究，结果发现全部病例Ｐ５３总阳性率为４３．５％，在脂肪肉瘤（４７．０％）中阳性率较高，而平滑肌肉瘤（７．１４％）中阳性率较低。Ｐ５３蛋白阳性表达与肉瘤组织分化程度有关，分化愈低其阳性率愈高，且在不同类型肉瘤中有一定差别，说明Ｐ５３抑癌基因突变在软组织肉瘤发生发展过程中起着重要作用。
cases of soft tissue sarcomas were studied inmmunohistochemically,by using monoclonal antibody against P 53 protein.The total positive rate is 43.58%(34 cases),and liposarcoma(47.05%),rhabdomyosarcoma(46.6%),fibrosarcoma(45.45%),leiomyoma(7.14%).The expression of P 53 is related to the tumors differentiation,and the types of sarcomas.It indicates that mutation of P53 gene play an important role in the development of soft tissue sarcomas.
