维甲酸治疗急性早幼粒细胞白血病(附11例分析)

The differenfiation chmotherapy of Retinoic Acid for acute promyelocytic leukaemia(APL)——With analysis of 11 cases

回顾分析应用维甲酸治疗急性早幼粒细胞白血病患者１１例，男５例，女６例，除１例因合并严重肺部感染及脑出血死亡外，其余均获完全缓解。本组资料通过观察患者体温、血象、骨髓变化、药物的作用及毒副作用等临床指标，显示维甲酸治疗急性早幼粒细胞白血病效果肯定、毒副作用轻、治疗过程中不诱发ＤＩＣ，病人耐受性好，经济文便，便于推广。

Eleven Patients with acute promyelocytic leukaemia(APL) were treated with RA.Ten cases acquired complete remission(CR)except for one patient who died of pulmonary infection and cerebral haemorrhage,the variation of temperature as well as blood routine and bone marrow smear was observed in each patient ,The details indicated that RA was very effective to APL and its side effect such as DIC during therapy was minimal.During the course of treatment,WBC counts of peripheral blood changed regularly,The clinical results showed that using fresh blood transfusion and low dose heparin concurrently was very important to DIC occurrence in APL,and combined chemotherapy was essential to the patient after complete remission(CR).