ER、PR在乳腺增生病中的定量表达及其临床意义

The Quantitative Expression and Clinical Significance of ER,PR in Hyperplastic Disease of The Breast

目的探讨ER、PR在乳腺增生性疾病中的定量表达及其临床意义。方法通过免疫组化SP法和定量分析技术检测乳腺单纯性增生、非典型增生(轻度、中度、重度)及导管内癌各20例中ER、PR的表达情况,并用20例正常乳腺组织作对照。结果与正常乳腺组织、单纯性增生相比,非典型增生、导管内癌中ER、PR的表达量增加,有显著性差异(P<0.05);ER、PR在中度非典型增生的表达量>50%,与轻度非典型增生比较有显著差异,而与重度非典型增生、导管内癌比较差异无显著性。结论ER、PR的异常表达可能发生在乳腺癌发生过程中的早期,其定量表达可作为早期诊断癌前病变并估计预后的有效指标。

Objective To explore the quantitative expression of estrogen receptor（ER） ,progesterone receptor（PR） in breast hyper- plasia and its Clinical significance. Methods The expression of ER and PR was examined by immunohistochemical S - P method and quantitative analysis technique in 20 eases a piece of epithelial hyperplasia of usual type, atypical hyperplasia（mild,moderate,severe） and intraductal carcinoma,which contrasted with 20 cases of usual breast. Results The difference of the expression of ER and PR between usual breast or epithelial hyperplasia of usual type and atypical hyperplasia or intraductal carcinoma was significant（ P 〈 0.05 ） ;the expression of estrogen receptor（ER） , progesterone receptor（PR） in breast moderate dysplasia 〉 50% , there was significant difference between moderate dysplasia and mild dysplasia; but no significant difference between moderate dysplasia and severe dysplasia,lntraductal carcinoma. Conclusions The abnormal expression of ER and PR may be an early event in the progression of breast carcinoma,it could be used for early diagnosis of breast premalignancy and as a effective mark to monitor the prognosis.