一种新型希夫碱及其3d,4f配合物的抗菌活性(英文)

Antibacterial Activity of a Kind of Novel Schiff Base and Its 3d,4f Complexes

用微量热法研究一种新型希夫碱及其3d,4f配合物(2L,2LZnYb)对大肠杆菌和金黄色葡萄球菌的抗菌活性,得到了在它们作用下大肠杆菌和金黄色葡萄球菌生长代谢的产热曲线,并且基于分析生长代谢和非生长代谢的产热曲线建立的热动力学方程,获得了它们的抗菌活性.结果表明,两种化合物(ZL,2LZnYb)对大肠杆菌的生长代谢有强的活性(IC50分别为6.1和5.1mg·L-1),但对金黄色葡萄球菌的生长代谢的活性弱得多(IC50分别为310.1和595.5mg·L-1).Zn和Yb的导入使化合物对大肠杆菌生长代谢的抑制作用稍微增加,但大大降低了对金黄色葡萄球菌的抑制作用.对于非生长代谢,两种化合物的活性有很大的差别.无论对大肠杆菌还是金黄色葡萄球菌,由于配体2L的导入,表现出显著的抑制作用,2L的MSC50为6.4和209.7mg·L-1.配体2L可能成为新的抗菌先导化合物.

The microcalorimetric method was used to study the antibacterial activity on the bacteria＇s multiplying metabolism and the non multiplying metabolism. The metabolism thermogenic curves ofEscherichia coli （E. coli） and Staphylococcus aureus （S. aureus）, under the action of the synthesized Schiff base and its 3d, 4f complexes （2L, 2LZnYb）, were obtained. The results showed that the multiplying metabolism and the non multiplying metabolism of bacteria could be analyzed by the thermogenic curves using the thermokinetic equations. On the multiplying metabolism, the two compounds （ZL, 2LZnYb） have strong activity for E. coli. （ICso （half-inhibitory concentration） is 6.1 and 5.1 mg·L^-1, respectively） and weak activity for S. aureus （ICso is 310.1 and 595.9 mg·L^-1, respectively）. The introduction of Zn and Yb with the compound slightly increased the inhibition on the multiplying metabolism of E. eoli but greatly decreased the effect on that of S. aureus. The activity of these two compounds showed great difference on the non multiplying metabolism. Regardless of E. coli or S. aureus, 2L just showed a notable inhibition and MSCso （the minimum stationary-cidal concentration 50） of 2L was 6.4 and 209.7 mg·L^-1 for the two microorganisms, respectively. Thus, 2L may become a novel kind of potential antibacterial candidate.