654—2治疗急性黄疸型肝炎的临床评价

CLINICAL EVALUATION OF ANISODAMINUM(654-2) TREATMENT IN ACUTE JAUNDICE HEPATITIS

６５４—２作为一种血管活性药物广泛应用于临床，本文观察了它对急 性黄疸型肝炎血液流变学及肝功能的影响，结果表明：６５４—２对退黄、隆酶时间与 对照组相比有显著差异（Ｐ＜０．０５）。全血高切粘度（２３０５１）、低切粘度（５．７５５－１）、 血浆粘度、红细胞凝集指数和红细胞沉降率亦有显著差异（Ｐ＜０．００１）。提示 ６５４－ ２能改善急性黄疸型肝炎病人肝脏微循环，保护肝细胞，促进肝细胞恢复。

Anisodaminum ,as a kind of blood vessel-active drug, has been widely used in clinic . It was observed that influence of 654-2 on hemorheology and liver function in actue jaundice hepatitis. These results showed a significant decrase of the time of dropping jaundice and resuing serum alanine aminotrarsferase (ALT ) in the treatment group, comparead with control group(p<0. 05). There were also significant difference in the blood viscosity of high shear rate(230s^(-1)),the blood viscosity of low shear rate (5. 75s^(-1)), plasma viscosity,erythrocyte aggregation index and erythrocyte sedimention rate (p<O. 001).