五味子对去卵巢肥胖大鼠体重及血脂等的影响

Effects of schizandra chinensis baill on body weight and serum lipid in ovariectomized obese rats

目的:观察五味子对去卵巢大鼠体重及血脂的影响。方法:切除3个月龄雌性Sprague-Dawley(SD)大鼠双侧卵巢,观察五味子对体重、摄食量、饮水量的影响,并测定血浆总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白、血糖、胰岛素及雌激素的水平。结果:体重和摄食量手术组明显高于假手术组(P<0.001),五味子组与手术组相比明显降低(P<0.01)。血浆总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白手术组都明显高于假手术组(P<0.001)。五味子组血浆总胆固醇、甘油三酯、高密度脂蛋白与手术组相比显著降低(P<0.01)。结论:五味子能明显抑制去卵巢大鼠摄食量和体重的增加,降低血浆总胆固醇、甘油三酯和高密度脂蛋白。

Objective To study the effects of schizandre chinensis baill （SCB） on body weight, food intake and plasma lipids in ovariectomized rats. Methods Female Sprague-Dawley rats aged 3 months were administered with Schizandre Chinensis Baill following surgical removal of their bilateral ovaries. The body weight and food and fluid intake were observed. Plasma levels of total cholesterol （TC）, triglyceride （TG）, low density lipoproteins （LDL-C）, high density lipoproteins （HDL-C）, glucose, insulin, and estrogen were determined. Results Body weight and food intake were remarkably higher in the operation group than in the sham-operation group （P 〈 0.001 ）but were markedly declined after SCB treatment （P 〈 0.001 ）. Plasma levels of TC, TG, HDL-C, and LDL-C obviously elevated in the ovariectomized rats as compared to those in the sham-operation group （P 〈 0.001 ）whereas they evidently decreased after administration with SCB （P 〈 0.01）. Conclusion Schizandre chinensis baill can significantly inhibit the ovariectomized rat＇s food intake and weight gain, and also decrease plasma levels of TC, TG, and HDL-C.