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白芍化学成分研究 被引量：48

Chemical constituents in root of Paeonia lactiflora
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摘要 目的对白芍进行化学成分研究。方法利用萃取、硅胶柱色谱、反相柱色谱和高效液相色谱法进行分离、制备和纯化,采用波谱技术进行结构确证。结果从白芍中分离鉴定了5个化合物,分别为芍药苷亚硫酸酯(Ⅰ)、芍药苷(Ⅱ)、芍药内酯苷(Ⅲ)、苯甲酰芍药苷(Ⅳ)和1,2,3,4,6-五没食子酰基葡萄糖(Ⅴ)。结论化合物Ⅰ为一新化合物。 Objective To study the chemical constituents in roots of Paeonia lactiflora. Methods The compounds were isolated by extraction, silica gel coloum chromatography, RP chromatography and HPLC. The structures were elucidated by various modern spectroscopic methods. Results Five compounds were isolated and identified as paeoniflorin sulfonate （ Ⅰ）, paeoniflorin （ Ⅱ ）, albiflorin （Ⅰ ）, benzoylpaeoniflorin （Ⅳ）, and 1, 2, 3, 4, 6-pentagalloyglucose （Ⅴ）. Conclusion Paeoniflorin sulfonate （ Ⅰ ） is a new compound.
作者 王巧 郭洪祝 霍长虹 史清文 叶敏 毕开顺 果德安
机构地区 河北医科大学药学院 北京大学医学部药学院 沈阳药科大学药学院
出处 《中草药》 CAS CSCD 北大核心 2007年第7期972-976,共5页 Chinese Traditional and Herbal Drugs
基金 国家科技部资助项目(2002BA906A29) 国家中医药管理局资助项目(2004ZX01)
关键词 白芍 芍药苷亚硫酸酯 芍药苷 the root of Paeonia lactiflora Pall. paeoniflorin sulfonate paeoniflorin
分类号 R284.1 [医药卫生—中药学]
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参考文献14

  • 1Ch P(中国药典)[S].Vol Ⅰ.2005.
  • 2Kaneda M, Iitaka Y, Shibata S. The absolute structure of paeoniflorin, albiflorin, oxypaeoniflorin and benzoylpaeoniflorin isolated from Chinese paeony root[J]. Tetrahedron, 1972, 28:4309-4317.
  • 3Tanaka T, Kataoka M, Tsuboi N, et al. New monoterpene glycoside esters and phenolic constituents of Paeoniae Radix, and increase of water solubility of proanthocyanidins in the presence of paeoniflorin[J]. Chem Pharm Bull, 2000, 48 (20): 201-207.
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二级参考文献12

  • 1Shibata S, Nakahara M. Paeoniforin, a glucoside of Chinese paeony root (1) [J]. Chem Pharm Bull, 1963,11(3):372-378.
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  • 7Shimizu M, Hayashi T, Morita N, et al. The structure of peniflorigenone, a new monoterpene isolated from Paeonia radix [J]. Chem Pharm Bull, 1983,31(2):577-583.
  • 8Lang H, Li S, McCabe T, et al. A new monoterpene glycoside of Paeonia lactiflora [J]. Planta Med, 1984,50(16):501-504.
  • 9Hayashi T, Shinbo T, Shimizu M, et al. Peonilactone A, -B, and -C, new monoterpenoids from paeony root [J]. Tetrahedron Lett, 1985,26(131):3699-3702.
  • 10Liang XT. Question of false appearance in the natural result "artificial result" [J]. Thesis Summary Collection of Academic Discussion of the Fourth National Natural Organic Chemistry (vol 1) (第四届全国天然有机化学学术讨论会论文摘要集(上)) [C]. Shanghai: Chinese Chemical Society, 1990.7.

共引文献35

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引证文献48

二级引证文献529

中草药
2007年 第7期

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