淫羊藿总黄酮对动物实验性心肌缺血及血液流变学的影响

Effects of total flavones from Herba Epimedii on experimental myocardial ischemia and hemorheology of animals

目的观察淫羊藿总黄酮(TFHE)对动物实验性心肌缺血及血液流变学的影响。方法以垂体后叶素制备大鼠急性心肌缺血模型和用高分子右旋糖酐制备大鼠急性血瘀模型,观察TFHE对急性心肌缺血模型大鼠心电图J点及急性血瘀模型大鼠血液流变学等指标的影响;观察TFHE对小鼠凝血时间的影响。结果TFHE高、中、低剂量(24、12、6mg/kg)组均能明显对抗急性心肌缺血大鼠心电图J点的偏移,能有效预防急性血瘀模型大鼠的全血黏度(高、中、低切变率)、红细胞压积以及纤维蛋白原量的升高;TFHE高、低剂量(34、17mg/kg)能明显延长小鼠凝血时间。结论TFHE对缺血心肌有一定的保护作用,可能与其改善血液流变学、降低血液黏度、防止血液凝固、改善冠脉循环有关。

Objective To observe the effects of total flavones from Herba Epimedii （TFHE） on the experimental myocardial ischemia and hemorheology of animals. Methods The model of acute myocardial ischemia of rats was established with pituitrin and the model of acute blood stasis was established with high-molecular dextran. The effects of TFHE on the electrocardiogram J-point of acute myocardial ischemia model and the hemorheology of acute blood stasis model were observed. Besides these, the effects of TFHE on coaglutaion time in mice were observed. Results As compared with the model groups, high-, middle-, and low-dosage groups （24, 12, and 6 mg/kg） of TFHE could obviously improve the abnormal electrocardiogram J-point of acute myocardial ischemia model, also could effectively prevent the ascending of whole blood viscosity （high-, middle-, and low-shear rate）, packed erythrocyte volume, and fibrinogen. High- and low-dosage groups （34 and 17 mg/kg） of TFHE could obviously lengthen the coaglutaion time in mice. Conclusion The results suggest that TFHE possesses protective effects on ischemic myocardium, which may better hemorheology, decrease the whole blood viscosity, prevent blood from coagulating and improve the circulatation of coronary artery.