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骨保护素的有关研究 被引量：7

Relevant research of osteoprotegerin
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摘要 骨保护素(osteoprotegerin,OPG)又称为破骨细胞生成抑制因子,主要通过与骨保护素配体结合而起作用。骨保护素不仅抑制破骨细胞生成,还抑制破骨细胞的骨吸收功能,现将有关研究进展作一综述。 Osteoprotegerin is also called osteoclastogenesis inhibitary factor. It plays a part in bonding osteoprotegerin ligand. It inhibits the production and action of bone resorption of osteoclast. The research and progress about osteoprotegerin were reviewed in this article.
作者 陈丽萍 杨富生 吴礼安
机构地区 第四军医大学口腔医学院
出处 《牙体牙髓牙周病学杂志》 CAS 2007年第6期361-363,共3页 Chinese Journal of Conservative Dentistry
关键词 骨保护素 破骨细胞 肿瘤坏死因子 osteoprotegerin osteoclast tumor necrosis factor
分类号 R780.2 [医药卫生—口腔医学]
  • 相关文献

参考文献19

  • 1王小斌,单其俊,马根山.骨保护素的研究进展[J].中国临床康复,2004,8(20):4066-4068. 被引量：3
  • 2Yasuda H,Shima N,Nakgawa N,et al.Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis inhibitory factor and is identical to TRANCE/RANKL[J].Proc Natl Acad Sci USA,1998,95(7):3597-3602
  • 3Lacey DL,Timms E,Tan HL,et al.Osteoprotegerin ligand is a cytokine that regulates ostoclast differention and avtivation[J].cell,1998,93(2):165-176
  • 4Yasuda H,Shima N,Nakagawa N,et al.Osteoclast differentiation factor is a lingand for osteoprotegerin/osteoclastogenesis inhibitory factor and is identical to TRANCE/RANKL[J].Proca Natl Acad Sci USA,1998,95 (7):3597-3602
  • 5Nagai M,Sato N.Reciprrocal gene expression of osteoclastogenesis inhibitory factor and osteoclast differentiation factor regulates osteoclast formation[J].Biodhem Biophys Res Commun,1999,257:719-723
  • 6Wan M,Shi X,Feng X,et al.Transcriptional mechanisms of bone morphogenetic protein-induced osteoprotegerin gene expression[J].J Biol Chen,2001,276:10119-10125
  • 7屈会起,邱明才.骨保护素的研究进展[J].国外医学（内科学分册）,2000,27(8):345-347. 被引量：9
  • 8Lacey DL,Tan HL,Lu J,et al.Osteoprotegerinligand modulates murine osteoc lastsurvival in vitro and vivo[J].Am J Pathol,2000,157(2):435-448
  • 9Tsurakai T,Udagawa N,Matsuza ki K,et al.Roles of macrophage-colony stimulatingfactor and osteoc last differentiation factor in osteoclastogenesis[J].J Bone MinerMetab,2000,18(4):177-184
  • 10Oshiro T,Shiotani A,Shibasaki Y,et al.Perimental movement of incisors in osteoprotegerin-deficient mice[J].Anat Rec,2002,266(4):218-225

二级参考文献74

  • 1Kawamoto S, Ejiri S, Hoshi K, Nagaoka E, Ozawa H. Immunolocalization of osteoclast differentiation factor in rat periodontium. Arch Oral Biol, 2002, 47(1)∶55-8
  • 2Wada N, Maeda H, Tanabe K, Tsuda E, Yano K, Nakamuta H, Akamine A. Periodontal ligament cells secrete the factor that inhibits osteoclastic differentiation and function: the factor is osteoprotegerin/osteoclastogenesis inhibitory factor. J Periodontal Res, 2001, 36(1)∶56-63
  • 3Shiotani A, Shibasaki Y, Sasaki T. Localization of receptor activator of NFkappaB ligand, RANKL, in periodontal tissues during experimental movement of rat molars. J Electron Microsc (Tokyo), 2001,50(4)∶365-9
  • 4Simonet WS,Lacey DL,Dunstan CR,el al.Osteoprotegerin.a noval secreted protein involved in the regulation of bone density.Cell, 1997,89∶309-319
  • 5Oshiro T, Shiotani A, Shibasaki Y, et al. Perimental movement of incisors in osteoprotegerin-deficient mice. Anat Rec 2002 ,266(4)∶218-25
  • 6Hofbauer LC, Khosla S, Dunstan CR, et al. The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption. J Bone Miner Res, 2000,15(1)∶2-12
  • 7Kanzaki H, Chiba M, Shimizu Y, et al. Periodontal ligament cells under mechanical stress induce osteoclastogenesis by receptor activator of nuclear factor kappaB ligand up-regulation via prostaglandin E2 synthesis. J Bone Miner Res, 2002, 17(2)∶210-20
  • 8Cheng X, Kinosaki M, Murali R, Greene MI. The TNF receptor superfamily: role in immune inflammation and bone formation. Immunol Res, 2003, 27(2-3)∶287-94
  • 9Coen G, Ballanti P,et al. Serum osteoprotegerin and renal osteodystrophy. Nephrol Dial Transplant, 2002, 17(2)∶233-8
  • 10Kong YY, Yoshida H, Sarosi I,et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature, 1999, 28,397(6717)∶315-23

共引文献23

同被引文献108

引证文献7

二级引证文献32

牙体牙髓牙周病学杂志
2007年 第6期

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