摘要
目的 探讨乳腺癌ER、PR与p53、c-erbB-2阳性表达与临床病理参数的关系。方法 病理诊断为乳腺癌44例,检测乳腺癌中ER、PR、p53、c-erbB-2的阳性表达情况与临床病理的关系。结果 (1)44例乳腺癌中,ER、PR、c—erbB-2、p53阳性表达分别为81.8%(36/44)、63.6%(28/44)、79.5%(35/44)和47.7%(21/44);ER阳性与p53阳性表达差异有统计学意义(P〈0.01);(2)ER、PR、p53、c-erbB-2阳性表达与年龄有关;(3)乳腺癌的病理分型与ER、PR、p53、c.erbB-2之间的表达无差异;(4)乳腺癌同侧腋窝组淋巴结内有、无癌的转移与ER、PR、p53、c-erbB-2之间阳性表达无差异(P〉0.05)。结论 乳腺癌患者检测ER、PR是对激素内分泌治疗有价值的指标,特别是ER和p53两者之间阳性差异有统计学意义(P〈0.01),提示预后好。
Objective To detect the positive expression of ER,PR, p53,c-erbB-2 in breast cancer and to elucidate their relationship with breast cancer pathological mechanism,age and lymph node involvement,point the relationship between the positive expression of ER, PR, p53, c-erbB-2 with clinical pathological mechanism. Methods The relationship between the positive expression of ER, PR, p53, c-erbB-2 in 44 cases of breast cancer diagnosed by clinical pathological was detected. Results ( 1 ) The positive expressions of ER, PR, c-erbB-2, p53, in 44 cases of breast cancer were 81.8% (36/44) ,63.6% (28/44) ,79.5% (35/44) and 47.7% (21/44) ,positive expression of ER and the p53 had remarkably difference( P 〈 0.01 );( 2 )Tlae positive expressions of ER. PR, p53, c-erbB-2 were connected with age; (3)The pathological mechanism of breast cancer had no difference with the expression of ER, PR,p53 and c-erbB-2; (4)The cancer metastasis in lymph nodes of armpit group had no difference with the expression of ER,PR, p53 and c-erbB-2 (P :〉 0.05). Conclusions To detect ER,PR in breast cancer patients are valuable for endocrine therapeutic hormone,especially the positive expressions of ER and the p53 have remarkably difference (P 〈 0.01 ),the prognosis is well.
出处
《中国基层医药》
CAS
2007年第6期941-942,共2页
Chinese Journal of Primary Medicine and Pharmacy