乳腺癌ER、PR、p53、c-erbB-2表达的临床意义

Expressions and clinical significance of ER,PR,p53.c-erbB-2 in breast cancer

目的 探讨乳腺癌ER、PR与p53、c-erbB-2阳性表达与临床病理参数的关系。方法 病理诊断为乳腺癌44例，检测乳腺癌中ER、PR、p53、c-erbB-2的阳性表达情况与临床病理的关系。结果 （1）44例乳腺癌中，ER、PR、c—erbB-2、p53阳性表达分别为81．8％（36／44）、63．6％（28／44）、79．5％（35／44）和47．7％（21／44）；ER阳性与p53阳性表达差异有统计学意义（P〈0．01）；（2）ER、PR、p53、c-erbB-2阳性表达与年龄有关；（3）乳腺癌的病理分型与ER、PR、p53、c．erbB-2之间的表达无差异；（4）乳腺癌同侧腋窝组淋巴结内有、无癌的转移与ER、PR、p53、c-erbB-2之间阳性表达无差异（P〉0．05）。结论 乳腺癌患者检测ER、PR是对激素内分泌治疗有价值的指标，特别是ER和p53两者之间阳性差异有统计学意义（P〈0.01），提示预后好。

Objective To detect the positive expression of ER,PR, p53,c-erbB-2 in breast cancer and to elucidate their relationship with breast cancer pathological mechanism,age and lymph node involvement,point the relationship between the positive expression of ER, PR, p53, c-erbB-2 with clinical pathological mechanism. Methods The relationship between the positive expression of ER, PR, p53, c-erbB-2 in 44 cases of breast cancer diagnosed by clinical pathological was detected. Results （ 1 ） The positive expressions of ER, PR, c-erbB-2, p53, in 44 cases of breast cancer were 81.8% （36/44） ,63.6% （28/44） ,79.5% （35/44） and 47.7% （21/44） ,positive expression of ER and the p53 had remarkably difference（ P 〈 0.01 ）;（ 2 ）Tlae positive expressions of ER. PR, p53, c-erbB-2 were connected with age; （3）The pathological mechanism of breast cancer had no difference with the expression of ER, PR,p53 and c-erbB-2; （4）The cancer metastasis in lymph nodes of armpit group had no difference with the expression of ER,PR, p53 and c-erbB-2 （P ：〉 0.05）. Conclusions To detect ER,PR in breast cancer patients are valuable for endocrine therapeutic hormone,especially the positive expressions of ER and the p53 have remarkably difference （P 〈 0.01 ）,the prognosis is well.