摘要
“非损伤微测技术”或称“无损微测技术”是上世纪末产生的一种用非损伤性的方法获取物体表面特异性离子和分子动态信息的新技术平台。该技术平台是微电子、计算机、精密机械加工、物理、数学、高分子化学、纳米技术及光学显微技术等多学科优秀成果的集成。“非损伤微测技术”可使研究人员在被测样品上获得其他技术难以测到的生理特征和生命活动规律,从而在理论研究和应用领域方面产生实质性的突破。“非损伤微测技术”平台还可以方便地与细胞和分子生物学技术、其他电生理技术和显微荧光成像技术配合使用,从而更全面地揭示各种生命现象及其本质。目前,“非损伤微测技术”平台已被多家科研机构、医院和制药公司所采用,其应用范围涵盖了生物学、生理学、神经生物学、环境科学、药理学、材料科学等诸多领域。文章较详细地介绍了非损伤微测技术及其在生物医学中的应用,其中包括植物、动物研究领域中与生物医学相关问题研究中的应用以及与其他技术结合的应用等。
Non-invasive micro-test technology （NMT） was born in the late 20th century, and is a new means to obtain dynamic information of specific ionic/molecular activities on material surfaces non-invasively. This technique is an integration of cutting-edge developments in the fields of micro-electronics, computer science, micro-mechanics, physics, mathematics, polymer science, nanotechnology and microscopy. It covers different temporal and spatial resolution domains from other traditional techniques, and its 3-dimensional measurement capability enables us to observe the physiological characteristics of biological phenomena which would be difficult or even impossible with other techniques. As a result, new breakthroughs have been made in both fundamental research and practical applications. For instance, a new mechanism of calcium ion absorption by mammalian bone has been discovered which may provide a more efficient way to provide calcium supplements to human beings. The integrated application of NMT with techniques in cellular and molecular biology, fluorescence microscopy and traditional electrophysiology will put us in a better position to piece together the puzzles about life. Up till now, NMT has been used by many research institutions, hospitals and pharmaceutical companies, and applications cover many scientific fields including biology, medicine, agriculture and so forth, and the list of applications is still growing.
出处
《物理》
CAS
北大核心
2007年第7期548-558,共11页
Physics
