大蒜素对局灶性脑缺血再灌注血液流变学改变的影响

Effects of allicin on changes of hemorheology in focal cerebral ischemia-reperfusion injury

目的:探讨大蒜素对大鼠局灶性脑缺血再灌注后血液流变学改变的影响。方法:用栓线法复制大鼠局灶性脑缺血(MCAO)再灌注模型,于脑缺血2 h,再灌注24 h时,观察不同剂量大蒜素对脑缺血再灌注大鼠的神经功能评分、脑梗死体积、脑含水量及血液流变学改变的影响。结果:与模型对照组比较,大蒜素高、中剂量(15,25mg.kg-1)能明显提高大鼠脑缺血再灌注的神经功能学评分,减轻大鼠脑缺血再灌注后的脑组织含水量的增加,减小脑缺血再灌注后大鼠的脑梗死体积;大蒜素高、中剂量(15,25 mg.kg-1)对脑缺血再灌注后大鼠全血黏度、高切还原黏度、高切相对黏度、低切相对黏度的升高有显著的抑制作用。结论:大蒜素对局灶性脑缺血再灌注损伤具有良好的保护作用,其机制可能与其抑制脑缺血再灌注后血液流变学改变有关。

Objective： To explore the effects of allicin on the changes of hemorheology in focal cerebral ischemia-reperfusion injury in rats. Method： Middle cerebral artery occlusion （MCAO） was used to make focal cerebral ischemia-reperfusion model by intravascular nylon filament occlusion. The protective effects of allicin at different doses were evaluated by investigating neurological function score, infarction volume and water content of brain. The changes of blood rheology were detected. Result： Compared with model group, allicin （15, 25 mg·kg^-1） increased the neurological function score and decreased the water content and infarction volume of brain in rats. Allicin （ 15, 25 mg·kg^-1 ） inhibited the increasing of the blood viscosity, high shear rate reduced viscosity, high shear relative reduced viscosity and low shear relative reduced viscosity. Conclusion： Allicin has protective effects on cerebral ischemiareperfusion injuries. The mechanism may be related to inhibit the increasing of hemorheology.