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基因型错误对数量性状精细定位的哈迪-温伯格不平衡指数的效应 被引量：3

The Effect of Genotyping Errors on Hardy-Weinberg Disequilibrium Measures for QTL Fine Mapping
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摘要 使用紧密相邻的标记位点且与标记基因频率无关的哈迪-温伯格不平衡(HWD)指数被用来对数量性状位点(QTL)进行精细定位.本文讨论了当存在基因型错误时HWD指数的性质.文章指出,当存在基因型错误时,对于在群体的标记基因频率已知的情形使用的两个HWD指数尽管受基因型错误的影响但仍然有效;而仅仅极端样本的标记基因频率已知的情形下使用的两个HWD指数同时与基因型错误和标记基因频率有关.计算机模拟表明,仅仅极端样本的标记基因频率已知的情形下使用的两个HWD指数在精细定位时会产生偏差,不适宜作精细定位. Hardy-Weinberg disequilibrium （HWD） measures that do not depend on marker allele frequencies have been proposed using dense markers to fine map a quantitative trait locus（QTL）. Here, we discuss the properties of HWD indices in the presence of undetected genotyping errors. We denote that, when there are undetected genotype errors, two indices being for use when marker allele frequencies in a study population are known are robust and powerful for fine mapping of QTLs, though they depend on genotype errors, but the other two indices being for use when marker allele frequencies in a study population are not known and are only known in the extreme samples depend not only on genotyping errors but also on marker allele frequencies. Simulations showed that the two HWD indices using for the case that marker allele frequencies in a study population are not known and are only known in the extreme samples are biased and not powerful for fine mapping.
作者 李玉梅 陈湘定 邓红文
机构地区 中南大学公共卫生学院 怀化学院数学系 湖南师范大学分子与统计遗传实验室
出处 《生物数学学报》 CSCD 北大核心 2007年第2期259-264,共6页 Journal of Biomathematics
基金 怀化学院资助科研项目
关键词 基因型错误 效应 哈迪-温伯格不平衡 精细定位 数量性状位点 Genotyping errors Effect Hardy-Weinberg disequilibrium Fine mapping Quantitative trait locus
分类号 Q343.17 [生物学—遗传学]
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参考文献10

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共引文献4

同被引文献23

  • 1李玉梅,向阳,邓红文,孙振球.An Entropy-based Index for Fine-scale Mapping of Disease Genes[J].Journal of Genetics and Genomics,2007,34(7):661-668. 被引量：2
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生物数学学报
2007年 第2期

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