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肾细胞癌中Ref-1/APE的表达特点及其意义 被引量：5

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摘要 目的探讨Ref-1/APE蛋白表达与肾细胞癌生物学行为的关系。方法应用免疫组织化学方法检测58例肾细胞癌和11例正常肾组织中Ref-1/APE的表达。结果所有肾细胞癌和正常肾组织均有Ref-1/APE的表达,但在细胞内的表达定位有所不同,肾细胞癌阳性颗粒表达部位以细胞核为主,并且Ref-1/APE的表达定位与肿瘤分级、分期密切相关,差异有显著性(P<0.01);11例正常肾组织中仅见肾小管上皮细胞表达。结论Ref-1/APE基因可能与肾细胞癌的发生、发展有关。检测Ref-1/APE的表达及移位于细胞质的情况可能为肾细胞癌的恶性程度判定、预后评估及进一步治疗提供依据。
作者 王志新 张刚 连树林 张海英 孔祥波
机构地区 吉林大学中日联谊医院泌尿外科 吉林省中医院 吉林大学基础医学院病理学教研室
出处 《中国老年学杂志》 CAS CSCD 北大核心 2007年第13期1277-1278,共2页 Chinese Journal of Gerontology
关键词 肾细胞癌 Ref-1/APE(氧化还原因子-1/脱嘌呤脱嘧啶核酸内切酶)
分类号 R737.11 [医药卫生—肿瘤]
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参考文献7

  • 1徐世平,吴本俨.APE/Ref-1对细胞因子的调节及与肿瘤的关系[J].中华肿瘤防治杂志,2006,13(8):630-634. 被引量：5
  • 2Moore DH,Micheal H,Tritt R,et al.Alterations in the expression of the DNA repair/redox enzyme APE/ref-1 in epithelial ovarian cancers[J].Clin Cancer Res,2000;6:602-9.
  • 3Misra RR,Ratnasinghe D,Tangrea JA,et al.Polymorphisms in the DNA repair genes XPD,XRCC1,XRCC3,and APE /ref-1,and the risk of lung cancer amongmale smokers in Finland[J].Cancer Lett,2003;191(2):171-8.
  • 4Wang D,Luo M,Kelleym R.Human apurinic endonuclease 1(APE1)expression and prog nostic significance in steosarcoma:enhanced sensitivity of osteosarcoma to DN A damaging agents using silencing RNA APE1 expression inhibition[J].Mol Cancer Ther,2004;3(6):679-86.
  • 5Angkeow P,Deshpande SS,Qi B,et al.Redox factor-1:anextra-nuclear role in the regulation of endothelial oxidative stress and apoptosis[J].Cell Death Differ,2002;9 (7):717-25.
  • 6Hall JL,Wang X,Adamson V,et al.Overexpression of Ref-1 inhibits hypoxia and tumor necrosis factor-induced endothelial cell apoptosis through nuclear factor-kappab-independent and-dependent pathways[J].Circ Res,2001; 88 (12):1247-53.
  • 7Kelley MR,Cheng L,Foster R,et al.Elevated and alteredexpression of the multifunctional DNA base excision repair and redoxenzyme Ape1 / ref-1 in prostate cancer[J].Clin Cancer Res,2001;7(4):824-30.

二级参考文献33

  • 1Xanthoudakis S,Curran T.Identification and characterization of Ref-1,a nuclear protein that facilitates AP-1 DNA-binding activ ity[J].EMBO J,1992,11(2):653-665.
  • 2Robson C N,Hickson I D.Isolation of cDNA clones encoding a human apurinic/apyrimidinic endonuclease that corrects DNA repair and mutagenesis defects in E.coli xth (exonuclease Ⅲ) mu tants[J].Nucleic Acids Res,1991,19(20):5519-5523.
  • 3Ordway J M,Eberhart D,Curran T.Cysteine 64 of Ref-1 is not essential for redox regulation of AP-1 DNA binding[J].Mol Cell Biol,2003,23(12):4257-4266.
  • 4Kakolyris S,Kaklamanis L,Giatromanolaki A,et al.Expression and subcellular localization of human AP endonuclease 1(HAP1/Ref-1) protein:a basis for its role in human disease[J].Histopathology,1998,33(6):561-569.
  • 5Koukourakis M I,Giatromanolaki A,Kakolyris S,et al.Nuclear expression of human apurinic/apyrimidinic endonuclease(HAP1/Ref-1) in head-and-neck cancer is associated with resistance to chemoradiotherapy and poor outcome[J].Int J Radiat Oncol Biol Phys,2001,50 (1):27-36.
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  • 7Kakolyris S,Kaklamanis L,Engels K,et al.Human apurinic endonuclease 1 expression in a colorectal adenoma-carcinoma sequence[J].Cancer Res,1997,57(9):1794-1797.
  • 8Moore D H,Michael H,Tritt R,et al.Alterations in the expression of the DNA repair/redox enzyme APE/ref-1 in epithelial ovarian cancers[J].Clin Cancer Res,2000,6 (2):602-609.
  • 9Tanner B,Grimme S,Schiffer I,et al.Nuclear expression of apurinic/apyrimidinic endonuclease increases with progression of ovarian carcinomas[J].Gynecol Oncol,2004,92(2):568-577.
  • 10Freitas S,Moore D H,Michael H,et al.Studies of apurinic/apyrimidinic endonuclease/ref-1 expression in epithelial ovarian cancer:correlations with tumor progression and platinum resistance[J].Clin Cancer Res,2003,9 (13):4689-4694.

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中国老年学杂志
2007年 第13期

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