氯磺酸催化合成α-氯代脂肪酸的工艺研究

Synthesis of alpha-chlorination of dodecanoic acid catalyzed by chlorosulfuric acid

以长链脂肪酸十二酸为原料,氧气为自由基捕集剂,进行氯磺酸催化合成α-氯代十二酸的千克量级反应工艺优化研究。实验结果表明,氯磺酸添加量为十二酸质量的2%、搅拌速度1000r/min、氯气流量40L/h、反应温度为120℃时,反应3h后千克量级反应α-氯代十二酸产率可达到96.4%。该工艺有望用于工业生产。

The kilogram-scale technique for preparation of alpha -chlorododecanoic acid was studied with dodecanoic acid as the material and oxygen as the radical scavenger, catalyzed by chlorosulfuric acid. A yield of 96.4% of alpha -chloro-fatty acid can be obtained in 3 hours under the following optimized conditions： m （chlorosulphonic acid） ： m （dodecanoic acid） = 2%, 1 000 rpm of stirring rate,and 40 L/g of chlorine flux rate at 120℃.