温度敏感型PCL-Pluronic-PCL水凝胶的合成与性能

A Thermosensitive PCL-Pluronic-PCL Biodegradable Block Copolymer Hydrogel

通过泊洛沙姆(Pluronic)引发己内酯(ε-CL)开环反应,合成了一种较低分子量的PCL-Pluronic-PCL多嵌段共聚物,并采用FT-IR和1H-NMR对其结构进行表征。这种PCL-Pluronic-PCL共聚物有良好的水溶性,并且当其水溶液浓度高于临界凝胶浓度(CGC)时,随着温度的变化呈现出凝胶-溶胶转变特性。采用试管法测试共聚物水溶液的凝胶-溶胶转变。该共聚物水凝胶在可注射药物控制释放系统等方面有着广泛的潜在应用价值。

Biodegradable block copolymers containing Pluronic and polycaprolactone （PCL） were successfully synthesized by ring opening polymerization of ε-caprolactone （ε-CL） on Pluronic （PEG-PPG-PEG）, which were characterized by ^1H-NMR and FT-IR spectra. The copolymers are dissoluble in water. And their aqueous solution displays gel-sol transition with temperature increasing when the concentration above corresponding critical gel concentration （CGC）. The gel- sol phase diagram was recorded using the test tube-inverting method. This hydrogel may have perspective application in injectable drug-delivery systems.