儿童初治肺结核耐药性测定

Drug risistance of micobacterum tuberculosis in primary treatment children with pulmonary tuberculosis

126例儿童初治菌阳肺结核病人菌株对7种主要抗结核药物的耐药性测定结果，74株耐药，耐药率58.7％。耐SM、INH、RFP者分别为40.5％、38.9％和24.6％。其高低浓度耐药顺序基本相同。耐1药者占16.6％;耐2药者为25.4％;耐3药者11.9％;耐4药以上者4.8％。同时耐HS者占27.4％;而HR者为15.9％;耐RS者15.9％;耐HRS者12.7％。提示高耐药性是导致临床化疗失败的主要原因，故应高度重视化疗原则和管理水平。

The detecting rushs indicate that the rate of the drug resistance of M.tuberculosis in 126 cases of the primary treatment children with the pulmonary tuberculosis, 58. 7% (74 cases). The rates of resistance on SM, INH and RFP are 40.5%, 38. 9% and 24. 6% respectively. The sequence of the drug resistance from hieght to low consentrantion is same 'basically. The rates of the resistance on one drug, tow,three and four drugs are 16. 6%,25. 4%, 11. 9% and 4. 8% respectively.The rates of the resistance on INH as well as SM, INH as well as RFP and RFP as well as SM are 27. 4%, 15. 9% and 15. 9% respectively. The rate of the resistance simultaneously on INH, RFP and SM is 12. 7%. The researched results points out that the hieght drug resistance is a main cause of the resulting to clinical chemotherapy failures.