1870株致病菌感染概况及敏感性情况

The general situation of infection and drug-sensitivity of 1870 pathogenic strains

目的了解临床标本中主要致病菌分布及敏感性分析，指导抗生素的选择及合理治疗方法对我院1994～1996年临床分离的1870株细菌的分布及敏感性、耐药性进行分析，1996年与1994年的结果进行比较，并将1995年的结果与北京地区5家教学医院同年的结果进行比较。结果分离菌株主要分布于呼吸道、消化道、泌尿道、血液及骨髓。G＋菌占10.5％，G-菌占89.5％，占明显优势。沙门氏菌对头孢唑啉和哌拉西林的耐药性明显降低（P＜0.01），大肠埃希氏菌对氨苄西林和氟嗪酸的耐药性明显增高（P＜0.01），其余菌株无明显差异。抗生素敏感性覆盖率最高的是复达欣，其次为丁胺卡那，最低者氨苄西林。大肠埃希氏菌、假单胞菌对哌拉西林的耐药率，克雷伯杆菌属对西力欣的耐药率，肠肝菌属对哌拉西林的耐药率均高于北京地区。结论本组资料显示不断监测和分析菌丛的变化及对不同抗生素耐药性出现的频率和耐药谱至关重要。

Objective To study the distribution and drug-sensitivity of predominant pathogenic strains, in order to instruct choice of antibiotics and rational therapy.Methods The distribution and. drug--sensitivity of 187o pathogenic strains isolated from clinical samples in our hospital from 1994 to 1996 were analyzed, and compared with those of five hospitals in Beijing. Results The pathologic strains primaryly distributed in respiratory tract,tigestive tract urinary tract, blood and row, in which, the grampositive bacilli takes 1o. 5%, gram-negative bacilli 89.5%. The resistance of salmonella to CEZ and PIP in 1996 more decreased than that of 1994 (P＜0. 01), while, of E, colt to AMP and OFL significantly increased (P＜0. 01). Amon 1o antibiotics, CAZ has the highest bactericidal power followed by AMK, the lowest is AMP. The rate of drug-resistance of E. colt and pseudomonas to CAZ, kleb6iella. p to FRX and Enterobactiaceae to PIP is higher than that of in Beijing district. Conclusions Contineously detecting the changes of conoly and drug-sensitivity should be paid great attention by clinicians.