UVA与UVB治疗寻常型银屑病临床对照研究

The clinical study of psoriasis vulgaris with UVA and/or UVB

目的:评价煤焦油软膏外用联合UVA+UVB照射治疗寻常型银屑病的疗效及安全性。方法:91例寻常型银屑病患者外用煤焦油软膏联合UVA+UVB照射,并与53例寻常型银屑病患者外用煤焦油软膏联合UVA、51例联合UVB照射进行对比观察。结果:治疗8周后UVA+UVB组痊愈率为63.74%,总有效率为98.90%,明显高于UVA组和UVB组;治疗2周、4周、6周和8周后PASI评分均较治疗前明显下降,UVA+UVB组与UVA组、UVB组对比有显著性差异;1年内复发率UVA+UVB组27.66%,明显低于UVA组或UVB组。结论:外用煤焦油软膏联合UVA+UVB照射治疗寻常型银屑病较单纯联合UVA或UVB照射疗效高、复发率低。

Objective： To evaluate the efficacy and safety of UVA ＋ UVB combined with topical coal tar ointment in the treatment of psoriasis vulgaris. Methods： Ninety - one patients with psoriasis vulgaris were treated with UVA/ UVB combined with topical coal tar ointment, compared with 53 patients of psoriasis vulgaris treated with UVB and topical coal tar ointment, and 51 patients treated with UVB plus topical coal tar ointment. Results： After 8 week treatment, the cure rate and the total response rate in the group treated with coal tar ointment combined with UVA/ UVB were 63.74% and 98.90%, which was significantly higher than those treated with UVA and UVB combined with topical coal tar ointment. After 4, 6 and 8 week treatment, the score of PASI in all groups was lower than that before treatment. The score of PASI in UVA/UVB group was decreased more than that in other two groups. The recurrent rate in UVA/UVB group was 25.86% within one year, which was significantly lower than those in the groups treated with UVA or UVB. Conclusion： The regimen of UVA/UVB irradiation in combination of topical coal tar ointment in the treatment of psoriasis vulgaris is effective and safety.