曲尼司特治疗特应性皮炎临床疗效观察

Efficacy of tranilast in the treatment of atopic dermatitis

目的:观察曲尼司特治疗特应性皮炎的疗效与安全性。方法:采用随机双盲、安慰剂平行对照的方法,将入选患者随机分为试验组与对照组,分别接受曲尼司特和安慰剂的治疗,同时两组患者均外用丝塔芙保湿润肤霜。对皮肤病变范围、皮损严重程度、瘙痒和睡眠影响程度进行临床观察,用SCORAD评分系统进行评估。结果:治疗组23例基本痊愈6例,显效9例,有效4例,无效4例,总有效率为65.22%,对照组总有效率为22.73%,两组有显著性差异(P=0.0216);治疗组患者治疗前后SCORAD评分有统计学差异(P<0.05)。治疗过程中治疗组不良反应仅为4.35%,且症状轻。结论:曲尼司特治疗特应性皮炎安全、有效。

Objective： To determine the efficacy and safety of tranilast in the treatment of atopic dermatitis （AD）. Methods： The AD patients were randomly divided into two groups who received either tranilast or placebo for 1 month, and in combination with Cetaphil moisturizing cream. The severity, itch and affection on sleep were evaluated with SCORAD system. Results： Among the 23 patients treated with tranilast for four weeks, the clinical efficacy was as follows： full recovery 6 cases, significant improvement 9 cases, moderate improvement 4 cases and no change or mild improvement 4 cases, giving a total response rate of 65.22%, while in the control group, the total response rate was 22.73% with a significant difference between the two groups （ P = 0.0216）. The SCORAD score also had statistical difference before and after treatment （ P 〈 0.05 ）. The side - effect was mild （4.35 % ） in the treated group. Collusion： The results suggest that tranilast is effective and safe in the treatment of atopic dermatitis.