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PANDER与β细胞凋亡 被引量：1

PANDER andβcell apoptosis
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摘要 胰腺衍生因子(PANcreatic DERived factor,PANDER)是新发现的、由胰岛α细胞和β细胞分泌的一种分泌型细胞因子,与β细胞凋亡密切相关。本文对PANDER的分子结构、生物学功能及其作用机制和影响因素作一综述,为1型糖尿病的诊断与治疗提供新思路。 PANDER （PANcreatic DERived factor, FAM3B）, a newly discovered secreted cytokine, is secreted from beth pancreatic α-cell and β-cell, and is found play some roles in β cell apoptosis. This review focuses on the molecular structure, biological function, mechanism of action and influential factors of PANDER. It will be useful to elucidate the pathogenesis in type 1 diabetes and provide a new idea in the diagnosis and treatment of type 1 diabetes.
作者 袁扬 孙子林
机构地区 东南大学中大医院内分泌科
出处 《国际内分泌代谢杂志》 2007年第4期259-260,266,共3页 International Journal of Endocrinology and Metabolism
关键词 PANDER Β细胞 细胞凋亡 细胞因子 1型糖尿病 PANDER Pancreatic β-cell Apoptosis Cytokine Type 1 diabetes mellitus
分类号 R587.1 [医药卫生—内分泌]
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参考文献11

  • 1Cao XP, Gao ZY, Robert CE, et al. Pancreatic-derived factor (FAM3 B), a novel islet cytokine, induces apoptosis of insulin-secreting beta-cells. Diabetes, 2003,52: 2296-2303.
  • 2Burkhardt BR, Yang MC, Robert CE, et al. Tissue-specific and glucoseresponsive expression of the pancreatic derived factor (PANDER) promoter. Biochim Biophys Acta, 2005,1730 : 215-225.
  • 3Zhu Y, Xu G, Patel A, et al. Cloning, expression, and initial characterization of a novel cytokine-like gene family. Genomics, 2002, 80: 144- 150.
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  • 5Yang J, Gao Z, Robert CE, et al. Structttre-function studies of PANDER, an islet specific cytokine inducing cell death of insulin-secreting beta cell. Biochemistry ,2005,44:11342-11352.
  • 6Yang J, Robert CE, Burkhardt BR, et al. Mechanisms of glucose-induced secretion of pancreatic-derived factor (PANDER or FAM3B) in pancreatic beta- cells. Diabetes, 2005,54: 3217-3228.
  • 7Xu WZ, Gao ZY, Wu JM, et al. Interferon-y-induced regulation of the pancreatic derived cytokine FAM3B in islets and insulin-secreting βTC3 cells. Molecular and Cellular Endocrinol, 2005,240: 74-81.
  • 8Can X, Yang J, Burkardt BR, et al. Effects of overexpression of pancreatic derived factor (FAM3B) in isolated mouse islets and insulin-secreting betaTC3 cells. Am J Physiol Endocrinol Metab, 2005,289: E543-E550.
  • 9Burkhardt BR, Greene SR, White P, et al. PANDER-induced cell-death genetic networks in islets reveal central role for caspase-3 and cyclin-dependent kinase inhibitor 1 A ( p21 ). Gene, 2006,369:134-141.
  • 10Oyadomari S, Takeda K, Takiguchi M, et al. Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway. Proc Natl Acad Sci U S A,2001,98:10845-10850.

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国际内分泌代谢杂志
2007年 第4期

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