拉西地平防治大鼠慢性常压缺氧性肺动脉高压的实验研究

Study on preventing and treating chronic hypoxic pulmonary hypertension by Lacidipine in rats

采用慢性常压缺氧４周的ＳＤ大鼠进行实验，评价拉西地平对缺氧性肺动脉高压的防治作用。经导管测肺动脉压（Ｐｐａ）、颈动脉压（Ｐｃａ）；用放免法检测同步取自颈动脉、肺动脉和颈静脉三个部位血浆的内皮素。结果：拉西地平能阻抑缺氧大鼠Ｐｐａ的升高；外周血血浆ＥＴ水平不能反映肺动脉压的变化。

o explore lacidipine in preventing and treating hypoxic pulmonary hypertension (HPH),the pulmonary artery pressure (P pa ),cervical artery pressure (P ca ) and plasma endothelin (ET) concentrations were measured by right catheter and radioimmunoassay in rats.The blood samples were obtained from cervical artery,pulmonary artery and cervical vein.The results of experiment indicated that lacidipine could prevent the increase of P pa in rats exposed to hypoxia for 4 weeks,but didnt decrease P pa and P ca of rats in normal condition.The difference of the level of plasma ET between peripheral arterial blood and peripheral vein blood wasnt significant statistically.The level of plasma ET in peripheral blood couldnt reflect the change in P pa .