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国产吉西他滨联合顺铂治疗晚期非小细胞肺癌的临床观察

The clinical observation of treatment of advanced non-small-cell lung cancer with gemcitabine(made in China) combined with cisplatin
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摘要 目的:观察国产吉西他滨(GEM,泽菲)联合顺铂(PDD)治疗晚期非小细胞肺癌(NSCLC)的疗效及毒性反应。方法:34例NSCLC患者采用GP方案(GEM 1000mg/m2,第1、8天静脉滴注,PDD40mg/m2,第8、9天静脉滴注),21d为1周期,全组病例均接受2个或2个周期以上治疗。结果:34例患者共化疗87个周期。总有效率(CR+PR)44.1%(15/34)。毒副作用以白细胞和血小板下降为常见,但均可耐受。结论:吉西他滨联合顺铂对晚期非小细胞肺癌有较好的疗效,且毒副反应可耐受,值得进一步研究及推广应用。 Objective: To investigate the efficacy and toxicity of gemcitabine made in china(Gem) combined with cisplatin(PDD) as chemotherapy for patients with advanced non-small lung Cancer (NSCLC). Methods: 34 cases were treated with GP regimen: GEM 1000mg/m2 dl,d8 iv infusion, PDD 40mg/m2 d8, d9 iv infusion, 21 days for one cycle, and all patients received 2 or more cycles of therapies. Results: 34 patients were given 87 cycles of therapy and the overall response rate was 44.1%( 15/34); The main toxicities were leucopenia and thromboeytopenia. Conclusion: GP regimen is effective and well tolerable for advanced non-small-cell lung cancer and worth using widely.
作者 张荣生
出处 《大理学院学报(综合版)》 CAS 2007年第6期24-25,共2页 Journal of Dali University
关键词 非小细胞肺癌 化疗 吉西他滨 顺铂 Non-small-cell lung cancer chemotherapy Gemcitabine Cisplatin
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  • 1Soto Parra HJ,Cavina R,Antonelli G,et al.Superiority of three week vs four week schedule of cisplatin(CDDP) and gemcitabine(GEM):Results of a randomized phaseⅡstudy〔J〕[].Lung Cancer.2000
  • 2Paul A,Bun J.Triplet chemotherapy with gemcitabine,a platinum,and a third agent in the treatment of advanced non-small cell lung cance〔rJ〕[].Seminars in Oncology.1999
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