姐妹染色单体交换检测的临床应用

Clinical application of sister chromatid exchanges

目的:了解在肿瘤细胞中、一些药物、致畸物引起的突变细胞中姐妹染色单体交换(SCE)率的变化。方法:查阅近几年来有关文献资料,了解SCE率改变情况。结果:肿瘤细胞及突变细胞中SCE率与正常组相比较均有显著性差异。结论:姐妹染色单体交换作为一种简便而又敏感的遗传学指标,可以快速筛选致突变物、致癌物,在毒理、临床、环境诱变和肿瘤研究等领域中的应用十分广泛。

Objective： To study the changes of sister chromatid exchange （SCE） rate in the mutator cell of tumor cell and mutagenized by drug or teratogen. Methods： To review the documents and summarize the changes of SCE rate. Results： The SCE rate all had significant differences in contrast with normal groups. Conclusion： SEC rate could cull teratogen and carcinogen speedily as a simple and convenient and sensitive index of genetics. It could be applied widely to domain as toxicology, clinical medicine, environment mutagenicity, tumor research and so on.