动脉留置导管滴注溶栓药物治疗脑梗死临床分析

Cerebral thrombosis treated with thrombolytic agent given through artery retention catheter

目的评价动脉留置导管介入溶栓治疗脑梗死临床疗效及安全性。方法将60例脑梗死患者按发病时间分成A、B、C三组,其中A组随机分成A1组和A2组,A1组治疗后留置导管,通过导管在术后常规给药,A2组则在术后静脉给药。对所有入选患者进行局部留置导管灌注溶栓及术后注药等综合治疗,并进行治疗前及治疗后3 d血管计数,同时对治疗前和治疗后14 d2、1 d神经功能缺损程度及生活状态进行评分。结果各治疗组治疗后与治疗前比较,血管计数差异有统计学意义(P<0.05);治疗后21 d与治疗前比较,神经功能缺损程度及生活状态评分差异有统计学意义(P<0.05);与其他各组比较,A1组的显效率和有效率显著升高(P<0.05)。结论采用介入方法局部灌注溶栓加术后导管给药治疗脑梗死是安全、有效的,且时间越早效果越好。

Objective To investigate the efficacy and safety of thrombolytic agent in treatment of cerebral thrombosis through artery retention catheter. Methods Sixty patients with cerebral thrombosis were divided into groups A, B and C according to onset time. Group A was subdivided into groups A1 and A2; group A1 treated through retention catheter after thrombolysis while group A2 intravenously. All patients were treated by thrombolysis through catheter. The vessel counts were recorded before and 3d after treatment, ESS grades were evaluated before and 14 d,21 d after treatment. Results Compared with before treatment,the vessel counts 3d after treatment and the ESS grades 21 d after treatment showed statistically significant difference（ P 〈 0.05 ）. Compared with other groups, the marked improvement rate and effective rate increased in group A1 （ P 〈 0.05）. Conclusions The thrombosis therapy through artery retention catheter is safe and effective, and earlier, the better.