红霉素对14例人胃肠动力的影响

EFFECTS OF ERYTHROMYCIN ON HUMAN GASTROINTESTINAL MOTILITY

为了研究红霉素治疗胃瘫的作用。14例成人给于静脉注射（7mg／kg）或口服（500mg）红霉素，并进行胃肠测压。结果显示静往红素素后胃肠道传播性肌电综合波消失，代之以不规则的收缩波形，其收缩波数目从19个增加至63个（P＜0．01），收缩波幅从6．67～10kPa增高至＞13．33kPa。口服组在口服红霉素后胃肠道传播性肌电综合液数增加，从6个（MopatingMotorComplex，MMC）上升至15个，周期明显缩短（P＜0．05）。与胃不同，小肠在红霉素静注后收缩波数明显减少甚至消失。结论：红霉素具有促进胃动力的作用，而对小肠无明显作用，故适用于治疗胃瘫，而对假性肠梗阻疗效可能不佳。

PURPOSE To evaluate the effects of erythromycin on human gastrointestinal motility.METHODS 14 Volunteers were given either intravenous (7 mg / kg) or oral (500 mg) erythromycin. The gastrointestinal motility was recorded and compared before and after the administration of the drug.RESULTS Gastric MMC was interrupted after i.v. erythromycin and replaced by irregular contraction pat-tern. The contracts of stomach were increased from 19 to 63 (P< 0.01 ) and the amplitude was increased from 6.67 ～ 10 kpa to > l3.33 kpa. In the oral erythromycin group the number of MMC increased from 6 to 15 and the du-ration was decreased (P< 0.05). Different from the stomach the contract of small intestine was significantly de-creased after the erythromycin administration.CONCLUSIONS As erythromycin has different effects on stomach and small intestine it can be used for treatment of gastroparesis but not for pseudo obstruction of intestine.