抗氧化治疗伴异常角化的皮肤病

Application of antioxidants in the treatment of dermatosis associated with abnormal keratosis

越来越多的研究发现，氧自由基等过氧化物在许多疾病的发生过程中起着作用。目前，有些研究也显示氧自由基可能会导致表皮细胞的异常角化，因此，在许多伴有异常角化的皮肤病，如湿疹、银屑病、鱼鳞病、放射性皮炎、扁平苔藓等疾病的治疗中，开始采用抗氧化这种新的治疗措施，对此的研究正引起普遍关注。

More and more researches have demonstrated that superoxides including oxygen free radicals play an important role in the pathogenesis of many diseases. Recently, some studies have shown that oxygen free radicals could induce abnormal keratinization. So, some antioxidants like superoxide dismutase （ SOD ） have been tried to treat dermatosis associated with abnormal keratosis, such as eczema, psoriasis, ichthyosis, radiodermatitis, lichen planus, and so on. These findings are attracting extensive attention of dermatologists. The action mechanism of oxygen free radicals and recent advances of antioxidants in the treatment of skin diseases associated with abnormal keratosis are reviewed in this paper.