白癜风相关环境因素研究回顾

Vitiligo-assoeiated environmental factors： a review

白癜风是一种常见的色素脱失性皮肤病，病理上主要表现为黑素细胞的减少或消失。白癜风的发生受遗传与环境因素的共同影响。环境因素的参与，可能使各地白癜风患病率产生较大的差异．并使遗传度的值降低。白癜风相关的环境因素包括外伤、化学因素、精神因素及暴晒／晒伤等。不同环境因素间及遗传与环境因素间的相互作用可能也影响白癜风的发生。

Vitiligo is a common depigmented disorder with unclear etiology and pathogenesis, It is pathologically manifested as a decrease or loss of melanoctyes. Its development is affected by genetic and environmental factors. The involvement of environmental factors may cause a difference in the incidence of vitiligo in different area, and a reduction of heritability of vitiligo. It has been documented that vitiligo-associated environmental factors include trauma, chemical agents, psychological factors and sun exposure. Moreover, interactions between genetic and environmental factors or among environmental factors might influence the disease＇s development.