特应性皮炎患者血浆中P物质的测定及其临床意义

Detection of substance P in patients with atopic dermatitis and its significance

目的探讨特应性皮炎患者血清中P物质水平及其临床意义。方法用放射免疫法测定35例特应性皮炎患者血浆中P物质浓度,观察P物质与疾病严重程度积分及嗜酸粒细胞数的关系。结果特应性皮炎患者血浆中P物质浓度明显高于正常人对照(P<0.01),且疾病的EAS(?)评分和Rajka严重度积分与P物质浓度呈显著正相关,r分别为0.95和0.86,P均<0.01。特应性皮炎患者外周血嗜酸粒细胞数明显高于正常人对照(P<0.01),并且与疾病的严重度呈正相关(与EASI评分r=0.42,P=0.011,与Rajka严重度积分r=0.42,P=0.013):特应性皮炎患者血浆中P物质浓度与外周血嗜酸粒细胞数呈正相关(r=0.43,P=0.009)。结论P物质对判断特应性皮炎活动性可能有一定价值;P物质可能与嗜酸粒细胞共同参与特应性皮炎发病。

Objective To explore the serum level of substance P and its clinical significance in patients with atopic dermatitis （ AD ）. Methods The plasma level of substance P was measured by radioim- munoassay （ RIA ） in 35 patients with AD and 24 healthy controls. The correlation of substance P level with the disease severity [ eczema area and index （ EASI ） score and Rajka scores ] and eoginophil count was assessed. Results The plasma level of substance P was significantly higher in AD patients than that in normal controls （P 〈 0.01 ）, and positively correlated with the EASI score and Rajka score（ r= 0.95, 0.86 respectively, both P 〈 0.01 ）. The eoginophil count in peripheral blood was also increased in AD patients as compared with that in the controls, and positively correlated with the EASI score and Rajka score （ both r = 0.42, P 〈 0.05 ）. A positive correlation was also found between the plasma level of substance P and eosinophil count in AD patients （ r = 0.43, P 〈 0.05 ）. Conclusions Substance P may be a useful parameter in the evaluation of AD activity, and it may participate in the pathogenegis of AD by interacting with eosinophils.