丙氨酰谷氨酰胺双肽对胃癌化疗患者免疫功能的影响

Effect of Alanylglutaminai on Lmmune Function of Patients with Gastric Cancer Receiving Chemotheral

目的:观察丙氨酰谷氨酰胺双肽对胃癌化疗患者免疫功能的影响。方法:进展期胃癌化疗患者60例,随机分为对照组和试验组,对照组采用肠外营养(TPN)支持,试验组在TPN基础上加用丙氨酰谷氨酰胺双肽注射液。化疗后第1天开始对两组患者行营养支持,时间1周。于化疗前及化疗后第1天、第8天分别抽取外周血测定IgG、IgA、IgM和T淋巴细胞亚群CD_3^+、CD_4^+、CD_8^+,及(CD_4^+)/(CD_8^+)比值。结果:化疗后第1天,两组患者的各项免疫指标均有所下降;化疗后第8天,试验组的各项免疫指标均有所恢复,其中CD_3^+、CD_4^+和(CD_4^+)/(CD_8^+)比值与对照组有统计学差异(P<0.05)。两组患者在观察期间均无严重并发症。结论:含丙氨酰谷氨酰胺双肽的营养能有效改善和增强胃癌患者化疗后机体的免疫功能。

Objective： To evaluate the effect of alanylglutamine on immune function of patients with gastric cancer receiving chemotherapy. Method： sixty patients with gastric cancer receiving chemotherapy were randomizly divided into the control group （ receiving PN treatment, n = 30） and test group （ receiving alanylglutamine supplemented to PN treatment, n = 25 ）, All patients were treated for 7 days from the first day of chemotherapy, The levels of IgG, IgA, IgM, CD3^＋ ,CD4^＋ , and CD4^＋ ,CDs^＋ were measured before chemotherapy and on first and eighth day after therapy, Result： All the levels of immunal function were decreased on first day after chemotherapy in both two groups, But the levels of CD3^＋ ,CD4^＋ and CD4^＋ ,CD3^＋ were significantly different between two groups on eighth day after therapy（ P 〈 0.05 ）. No serious side effect occurred in both groups, Conclusion： Alanylglutamine can improve the immunal function of patients with gastric cancer receiving chemotherapy.