比较左氧氟沙星与阿莫西林在三联疗法中根除幽门螺杆菌的作用

To compare the efficacy of levofloxacin with amoxicillin for Helicober pylori eradication in triple therapy

目的比较左氧氟沙星与阿莫西林在三联疗法中根除幽门螺杆菌(Hp)的作用。方法选择213例符合条件的Hp阳性的慢性胃炎或消化性溃疡患者。随机分为两组。治疗组采取标准剂量的奥美拉唑(20mg,2次/日)加左氧氟沙星(200mg,2次/日),加呋喃唑酮(100mg,2次/日),治疗7天。对照组采取标准剂量的奥美拉唑(20mg,2次/日)加阿莫西林(1000mg,2次/日)加呋喃唑酮(100mg,2次/日),治疗7天。溃疡患者继用奥美拉唑20mg,1次/日,共3周。疗程结束4周后复查Hp,临床症状变化,溃疡愈合情况及不良反应等。观察Hp根除率,症状缓解率、溃疡愈合率及不良反应等。结果治疗组和对照组的症状缓解率、Hp根除率、溃疡治愈率、不良反应发生率分别为94.0%、88.0%、100.0%、16.0%和94.2%、83.7%、100.0%、8.1%。两组差异无显著性(P>0.05)。治疗组与对照组每例根除Hp费用分别为47.975元、38.875元。结论左氧氟沙星与阿莫西林在三联疗法中根除Hp疗效相仿且安全、经济,左氧氟沙星是根除Hp的理想新药,治疗组与对照组的方案均是根除Hp的理想方案。

Objective To compare the efficacy of levoffoxacin with amoxicillin for Helicobacter pylori（Hp） eradication in triple therapy. Methods A total of 213 Hp - positive patients suffering from chronic gastritis and peptic ulcer were randomized to treatment group and control group. The treatment group were administered standard omeprazole （20 mg, twice a day）, levofloxacin （200 mg, twice a day）and furazolidone （100 mg, twice a day ）for 7 days, while the control group received standard omeprazole （20 mg, twice a day）, amoxicillin （1000 mg, twice a day）and furazolidone（ 100 mg, twice a day）for 7 days. The patients with peptic ulcer were treated with omeprazole （20 mg, every day）for another three weeks. Four weeks later, the Hp eradication, symptoms, peptic ulcer healing and side - effects were observed. Results The symptom ameliorate rate, Hp eradication rate, peptic ulcer healing rate and side - effect rate between the treatment group and the control group were 94.0% and 94.2%, 88.0% and 83.7%, 100.0% and 100.0%, 16.0% and 8.1%, respectively. The difference was not significant （ P 〉 0.05 ）. The cost of anti - Hp therapy of patient was 47. 975 yuan （RMB） and 38. 875 yuan （RMB） in the treatment group and control group respectively. Conclusion The effects of levofloxacin and amoxicillin in triple therapy are the same safe and economic. The levofloxacine is new and ideal drug eradicating Hp. Both regiments of the treatment group and control group are ideal Hp eradication ones.