3-氧-11,12,13-三羟基桉烷-4-烯的简便全合成

Facile Total Synthesis of 3-Oxo-11,12,13-trihydroxyeudesm-4-ene

3-Oxo-11,12,13-trihydroxyeudesm-4-ene(1) was a highly oxygenated natural eudesmane isolated from traditional herbal medicine with an antiphlogostic and spasmolytic activity.For the purpose of pharmacological activity research on natural product 1 and its derivatives,a facile total synthesis of compound 1 starting from(+)-dihydrocarvone(2) was completed in an overall yield of 24%.The structures of all intermediates and product 1 were confirmed via 1H NMR,13C NMR,MS and IR techniques.The NMR data of compound 1 are in agreement with those of natural products.

3-Oxo-11,12,13-trihydroxyeudesm-4-ene （ 1 ） was a highly oxygenated natural eudesmane isolated from traditional herbal medicine with an antiphlogostie and spasmolytie activity. For the purpose of pharmacological activity research on natural product 1 and its derivatives, a facile total synthesis of compound 1 starting from （ ＋ ）-dihydroearvone（2） was completed in an overall yield of 24%. The structures of all intermediates and product 1 were eortfirmed via 1H NMR, is C NMR, MS and IR techniques. The NMR data of compound 1 are in agreement with those of natural products.