摘要
Capsaicin and(E)-4-hydroxy-3-methoxybenzyl-8-methylnon-6-enoate were important intermediate of medicine.This research proposed a new method for synthesizing them from 6-bromohexanoic ester by Wittig reaction to give(Z)-8-methyl-6-nonenoic acid(4),then treated by nitrous acid and NaNO2 to induce Z→E isomerization reaction of the carbon-carbon double bond,then followed by condensation reaction to give product in an overall yield of 31%.The method is more convenient than traditional methods.
Capsaicin and （E）-4-hydroxy-3-methoxybenzyl-8-methylnon-6-enoate were important intermediate of medicine. This research proposed a new method for synthesizing them from 6-bromohexanoic ester by Wittig reaction to give （Z）-8-methyl-6-nonenoic acid（4）, then treated by nitrous acid and NaNO2 to induce Z→E isomerization reaction of the carbon-carbon double bond, then followed by condensation reaction to give product in an overall yield of 31%. The method is more convenient than traditional methods.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2007年第7期1310-1312,共3页
Chemical Journal of Chinese Universities
