羊水细胞学检查在产前诊断中的应用

目的 采用羊水细胞培养作染色体核型分析以了解Downs综合征出现的频率与产前诊断之间的关系。方法 169例妊娠16～23周的孕妇进行羊膜腔穿刺术并细胞培养进行核型分析。结果 羊水细胞培养成功率95．27％，妊娠16-20周与妊娠21～23周的羊水培养成功率未见显著差异P〉0．05；其中检出5例21三体胎儿（先天愚型），2例X性连锁隐性遗传病作了产前诊断，1例9号染色体臂间倒位。结论 羊水细胞学检查在妊娠中期作为诊断Downs综合征的技术手段具有重要的作用。

Objective Gain the amniotic fluid cell culture to have chromosome karyotype analysis in order to learn the relationship between the frequency of present monglism and the standard of prenatal diagnosis.Methods 169 pregnant women who has gestated 16-23 weeks. Having amniocentasis and gain the amniotic fluid cell culture to have chromosome karyotype analysis.Results The successful rate of the amniotic fluid cell culture is 95.27%; there is no obviously difference of successful rate of the amniotic fluid cell between pregnant women who has gestated 16-20 weeks and 21 -23 weeks（P〉0.05）; four of these are monlisms, one of these are balanced translacation foetus,all have had inducodlabor. Meanwhile, have given two example of x-sex-limked inheritance a prenatal diagnosis. Conclusion Having amniocentasis play an important role in prenatal diagnosis.