摘要
目的研究玉树獐牙菜对小鼠实验性肝损伤的保护作用。方法采用一次性腹腔注射四氯化碳花生油(0.12%)方法制作染毒小鼠模型,分别给予不同剂量玉树獐牙菜对模型动物进行干预性保护,测定不同实验组动物的生化指标。结果该药能明显降低四氯化碳引起的小鼠血清ALT,AST升高;提高肝糖原含量。结论玉树獐牙菜对小鼠实验性肝损伤具有一定的保护作用。
Objective To investigate the protective effects of Herba Swertiae Mussotll liver injury in mice. Methods The model of liver injury was induced by intraperitoneal injection of earthnut oil mixed with CCl4 （0.12%） and the serum and liver tissue were collected. Biochemical indexes examination were detected. Results Herba Swertiae Mussotll obviously inhibited the increase of serum ALT and AST caused by CCl4 ; the glycogen content of liver was raised. Conclusion Herba Swertiae Mussotll can protect liver from damage when exposed to carbon tetrachloride.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2007年第7期1567-1568,共2页
Lishizhen Medicine and Materia Medica Research
基金
"十五"国家重大科技专项"创新药物和中药现代化"博士基金课题(No.2003AA2Z3538)
关键词
玉树獐牙菜
四氯化碳
肝损伤
肝糖原
Herba Swertiae Mussotll
Carbon tetrachloride
Liver injury
Glycogen of liver
