古钩藤镇痛抗炎药理作用的实验研究

A Research on Analgesia and Anti-inflammatory Effects of Gu Gou Teng

目的研究古钩藤水煎液的镇痛抗炎药理作用。方法采用小鼠热板法和扭体法镇痛实验,观察古钩藤水煎液的镇痛作用,观察对小鼠毛细血管通透性和二甲苯对小鼠耳廓肿胀的影响,观察其抗炎作用。结果古钩藤水煎液能显著提高小鼠痛阈值,降低毛细血管通透性,抑制由二甲苯所致的炎症反应,可显著减轻小鼠耳廓肿胀。结论古钩藤水煎剂有明显的镇痛和抗炎作用。

Objective To study the anti-inflammatory and analgesia actions of the Chinese medicine Gu Gou Teng solution. Methods The effect of Gu Gou Teng solution on analgesia was observed with the response of writhes and hot - plate tests. The effect of anti - inflammation was observed by mice inflammation models caused by dimethy benzene and mice models with reinforce permeability of abdominal cavity capillary caused by acetic acid. Results Gu Gou Teng solution had a prominent analgesia effect. It could restrain the capillary permeability resulted from imflammation by dimethybenzene. Conclusion Gu Gou Teng solution has significant effects of analgesia and anti - inflammatory on experimental mice.