摘要
目的建立消痛灵搽剂的质量标准。方法采用薄层色谱法（TLC）对处方中的栀子、姜黄、乳香、没药进行定性鉴别;采用反相高效液相色谱法（RP-HPLC）定量分析消痛灵搽剂中大黄素和大黄酚的含量。结果TLC分离效果好,斑点清晰;大黄素在0.248～1.984μg,大黄酚在0.292～2.336μg范围内呈良好的线性关系,平均回收率大黄素为99.7%,RSD（0.64%;大黄酚为99.2%,RSD（0.89%。结论该方法简便、准确、重复性好、能有效控制该复方制剂的质量。
Objective To establish the quality standard of Xiaotongling liniment. Methods Fructus Gardeniae, Rhizoma Curcumae longae, Olibanum, Myrrha were identified by TLC. The content of emodin and chrysophanol in Xiaotongling liniment was determined by RP-HPLC. Results The identified characteristics of chromatography were distinct and the spots were clear. The standard curve was linear within the range of 0. 248 - 1. 984μg for emodin and 0.292 - 2. 336μg for chrysophanol. The average recovery of emodin was 99, 7% with RSD of 0.64% ,with that of chrysophanol was 99.2% with RSD of 0, 89%. Conclusion The method is convenient,accurate and has a good reappearance. The preparation＇s quality can be controlled effectively.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2007年第7期1618-1619,共2页
Lishizhen Medicine and Materia Medica Research
基金
青海省重点科技攻关资助项目(No.2005-N-115)
